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ID 4595
Class Mammalia
Species Homo sapiens
Tissue Tibial articular cartilages
Sample Tissue
Disease type Osteoarthritis
Cell type Macrophages
Cell type (subtype) Macrophages
Cell marker CD163, CD14, FCGR3A, CD169
Frequency
PubMed ID 32616761
Journal Sci Rep
SCI IF 3.992
Evidence Classic macrophage marker genes (CD14, CD163 and FCGR3A) were highly expressed in IR-MΦ, I-MΦ and iFIB.R-MΦ diferentially expressed genes for signaling pathways related to immune regulation such as Stabilin 1(STAB1), a homeostatic receptor linking signals from extracellular to intracellular vesicular processes23, Tioredoxin Interacting Protein (TXNIP), an inhibitor of NF-κB activity24 and CD169, a macrophage specifc markerof immunoregulation and infammation25 (Fig. 2d and supplementary Fig. S2).
Title Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis
Authors Ching-Heng Chou et al.
Date 2020.7
Data available GSE152805