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ID 8852
Class Mammalia
Species Mouse
Tissue Stria vascularis
Sample Tissue
Disease type Normal
Cell type Spindle
Cell type (subtype) Spindle
Cell marker Slc26a4, P2rx2, Kcnj16
Frequency
PubMed ID 31920542
Journal Frontiers in Molecular Neuroscience
SCI IF 4.057
Evidence Violin plots demonstrate relative expression of these known SV cell type-specific genes across the four main cell types (Figures 2C, E). Confirmatory smFISH and immunohistochemistry demonstrates expression of these known markers for marginal cells (Kcne1, Kcnq1), intermediate cells (Cd44, Met), basal cells (CLDN11, ZO-1), and spindle/root cells (Slc26a4) (Figure 2F);Feature plots demonstrate expression of selected novel candidate genes in marginal cells (Abcg1, Heyl), intermediate cells (Nrp2, Kcnj13), basal cells (Sox8, Nr2f2), and spindle/root cells (P2rx2, Kcnj16) in both scRNA-Seq and snRNA-Seq datasets, respectively (Figures 3A, C)
Title Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis
Authors Soumya Korrapati et al.
Date 2019.12
Data available GSE136196