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ID 8840
Class Mammalia
Species Mouse
Tissue Spleen
Sample Tissue
Disease type MC38, B16-F10
Cell type T cells
Cell type (subtype) T cells
Cell marker Cd4, Foxp3, Cd8alpha, Cxcl9
Frequency
PubMed ID 32641748
Journal Commun Biol
SCI IF 4.165
Evidence The clusters identified expressed markers associated with each specific cell type such as Cd4, Cd8alpha, and Foxp3. In addition, there were increased levels of the M1 macrophage marker Nos2 and high expression of the T cell chemoattractant Cxcl9.
Title Absence of central tolerance in Aire-deficient Mouse synergizes with immune-checkpoint inhibition to enhance antitumor responses
Authors Asiel A Benitez et al.
Date 2020.7
Data available GSE151829, GSE151830, GSE151831