| Evidence |
We observed a distinct cluster ("Cluster 1, "_ig. 6 A) with a predominance of Trib1 cKO cells (Fig. 6 B). To further identify the identity of cells separated in each cluster, we queried the expression of a number of key T cell transcriptional markers (Fig. 6 C)._d4_nd either_oxp3_r_xcr5_xpression patterns suggested that CD4 T reg cells and CD4 T follicular helper cells mostly segregated to "Cluster 3" and "Cluster 4, " respectively. Based on the expression of genes including_d8, _xcr5, _dcd1, _cf7, _ox, _bx21, and_zmb, TEX_rogenitors appeared to group to "Cluster 2, " whereas terminally differentiated TEX_ells predominantly segregated to "Cluster 5." Cluster 1 distinctly consisted of a preponderance of cells expressing high levels of_lrg1 |
