Cell marker |
H2-Eb1, H2-Ab1, Fcgr4, H2-DMb1, H2-Aa , H2-DMa , CXCL9, CXCL10, CCL5, CCL8, IL2rg, Stat1, Fam26f |
Evidence |
Relative to myeloid cells from unresponsive tumors, those extracted from tumors responsive to anti_PD-1 treatment showed elevated levels of transcripts that encode class II MHC (H2-Eb1 [3.7-fold], H2-Ab1 [3.9-fold], H2-Aa [3.4-fold], H2-DMa [2.1-fold], H2-DMb1 [3.2-fold]), CXCL9 (12-fold), CXCL10 (_2-fold in clusters 0, 1, and 2), CCL5 (4.6-fold), CCL8 (5-fold), IL2rg (the gamma chain common to the IL-2, IL-4, IL-7, IL- 15, and IL-21 receptors; 2.4-fold), Stat1 (2.3-fold), Fcgr4 (4.6-fold), and Fam26f (9.5-fold; Fig. 7E). Thus, it appears that macrophages with an M1-type signature help polarize the TME toward an antitumor status. |