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ID 7788
Class Mammalia
Species Mouse
Tissue Muscle
Sample Tissue
Disease type Duchenne muscular dystrophy
Cell type Myonuclei
Cell type (subtype) MTJ
Cell marker Ckm, Col22a1, Lama2
Frequency
PubMed ID 33148801
Journal Proc Natl Acad Sci U S A
SCI IF 9.412
Evidence Another myonuclear cluster was labeled Cluster MTJ, as the myonuclei in this cluster selectively express Col22a1, a transcript that encodes a member of the collagen family that contributes to the stabilization of myotendinous junctions (MTJ) and strengthens skeletal muscle attachments during contraction. Additionally, a subset of genes expressed in the NMJ and MTJ clusters is also highly expressed in the nuclei of other mononucleated cell types (e.g., Lama2 in fibro/adipogenic progenitor [FAP] cells and tenocytes), but these genes are not expressed in the myonuclei of Clusters IIa, IIx, or IIb, supporting the uniqueness of Clusters NMJ and MTJ.
Title Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
Authors Francesco Chemello et al.
Date 2020.11
Data available GSE156498