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ID 7787
Class Mammalia
Species Mouse
Tissue Muscle
Sample Tissue
Disease type Duchenne muscular dystrophy
Cell type Myonuclei
Cell type (subtype) NMJ
Cell marker Ckm, Lama2, Chrne, Colq, Prkar1a, Col25a1
Frequency
PubMed ID 33148801
Journal Proc Natl Acad Sci U S A
SCI IF 9.412
Evidence We labeled another cluster as Cluster NMJ, since the myonuclei in this cluster express transcripts associated with the neuromuscular junction (NMJ), such as Chrne (coding for the acetylcholine receptor subunit epsilon), Colq, Prkar1a, and Col25a1 (21, 22). Additionally, a subset of genes expressed in the NMJ and MTJ clusters is also highly expressed in the nuclei of other mononucleated cell types (e.g., Lama2 in fibro/adipogenic progenitor [FAP] cells and tenocytes), but these genes are not expressed in the myonuclei of Clusters IIa, IIx, or IIb, supporting the uniqueness of Clusters NMJ and MTJ
Title Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
Authors Francesco Chemello et al.
Date 2020.11
Data available GSE156498