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ID 7735
Class Mammalia
Species Mouse
Tissue Multiple tissues
Sample NA
Disease type NA
Cell type Dendritic cells
Cell type (subtype) T-bet-CD11b+SIRPa+cDC2
Cell marker Cd11c, CLEC10A, MhcII, CD14, CD209A, CLEC12A, CX3CR1, IL1A, P2RX7, NKG2D, MGL2
Frequency
PubMed ID 31668803
Journal Cell
SCI IF 38.637
Evidence DCs defined as Lin(CD3, CD19, CD90)_ Ly6C_ CD64_ MHCII+ CD11c+, T-bet_ CD11b+ SIRPa+ cDC2s by 2 clusters (3 and 10). T-bet_ cDC2 clusters uniquely ex_x0002_pressed CLEC12A and could be further separated based on the expression of several cell surface markers by cluster 10 cells including CLEC10A (CD301a), CD209a, and NKG2D (Klrk1) (Figures 2A and S2C).Cd301b (Mgl2) was exclusively expressed by this cluster (Figure S2D) indicating that Mgl2+ cDC2s, previously reported in the skin and draining LN (Kumamoto et al., 2013), are akin to T-bet_ cDC2.Genes that defined T-bet_ cDC2s included Clec12a, Cx3cr1, Cd14, Il1a, and P2rx7
Title Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity
Authors Chrysothemis C. Brown et al.
Date 2019.1
Data available GSE137710