| Cell marker |
Col1a1, Col3a1, Acta, Dcn, Ddr2, vimentin4, Eln, Fn1, Tagln5 |
| Evidence |
aortic cells generated 5 clusters and better resolved specific cell types. For example, a cluster of mesenchymal cells that expresses vimentin4 and genes encoding secreted extracellular matrix proteins (Dcn, Col1a1, Ddr2, Col3a1, Eln, and Fn1) is present. The majority of these cells are fibroblasts, while a few are likely smooth muscle cells that express Acta2 and Tagln5, 6. Three Endothelial cells clusters are also present (Cdh5+ , Pecam1+ ), which are similar to the vascular Endothelial cellss (Cav1+ , Fabp4+ ) in the heart. Two of the clusters also express high levels of angiopoietin 1 receptor (Tek)7 , Endothelial cells specific molecular 1 (Esm1)8 , and Ehd39 . A cluster of antigen presenting cells is present (Ptprc+ , H2-Eb1+ , Cd86+), and the majority are most likely macrophages (Selplg+ , Cd14+ , Cd3e- , Cd19- ). |
