| Evidence |
Emanating from this core unit we identified a narrower group (cluster 4) expressing cell_x0002_cycle exit genes (Top2a, Prc1) as well as neuronal-specific genes Sstr2, Penk and Btg2, The latter gene was previously shown to induce neuronal differentiation (elGhissassi et al., 2002) and was identified in retinal progenitors (Trimarchi et al., 2008). These cycling cells progressed to a cluster aggregating early neuroblast transcription factors including Neurod4 and Pax6 (cluster 5) as well as genes known to promote axonal growth (Pcdh17) (Fig. S2C-E) (Hayashi et al., 2014).Following this neuroblast bottleneck furrow were three distinct branches. |
