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ID 5456
Class Mammalia
Species Mouse
Tissue Brain
Sample Tissue
Disease type Normal
Cell type Microglia cells
Cell type (subtype) Microglia cells
Cell marker Cx3cr1, P2ry12, C1qa
Frequency
PubMed ID 32221280
Journal Nat Commun
SCI IF 12.121
Evidence The clusters included ten Mouse cell types:astrocytes (SCL6A11 (ref. 36), NTSR2 (ref. 37)), oligodendrocytes (CLDN11 (ref. 38), CNP39), oligodendrocyte progenitor cells (OPC; PDGFRalpha, OLIG2)40, excitatory neurons (SYT1 (ref. 41), SNAP25 (ref. 42)), neuronal precursors (SOX11 (ref. 43), STMN2 (ref. 44)), vascular cells (MYL9 (ref. 45), MGP46), choroid cells (LCN2 (ref. 47), 1500015O10Rik48), Endothelial cellss (ITM2A49, FLT1 (ref. 50)), GABAergic neuron (NPY51, NR2F2 (ref. 52)) and Mouse microglia (P2RY12, C1QA, and CX3CR1). The only Human cell cluster, labeled Xeno MG, similarly expressed the microglial markers P2RY12, C1QA, and CX3CR1
Title Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric Mouse brain
Authors Ranjie Xu et al.
Date 2020.3
Data available GSE129178