| Evidence |
(1) dividing tumor cells that express high levels of genes associated with the cell cycle/division (Cdk1, Ccna2, and Cenpf) and elevated levels of Hh target genes such as Gli1, Gli2, and Ptch2; (2) quiescent tumor cells, in which cell-cycle/division genes have been downregulated but Hh pathway target genes remain activated; and (3) cells expressing low levels of cell-cycle/division genes and low levels of Hh target genes but elevated expression of genes related to neuronal differentiation, including Cntn2, Pax6, NeuroD1, Tubb3, and Gap43. |
