Search | Result
ID | 2349 |
---|---|
Class | Mammalia |
Species | Homo sapiens |
Tissue | Heart |
Sample | Tissue |
Disease type | coronary artery disease |
Cell type | Modulated smc |
Cell type (subtype) | Modulated smc |
Cell marker | FN1, LUM, CNN1 |
Frequency | |
PubMed ID | 31359001 |
Journal | Nat Med |
SCI IF | 36.13 |
Evidence | The decrease in expression of CNN1 and other markers of SMC differentiation in these cell groups was accompanied by a corresponding increase in markers of SMC modulation, including FN1 (Fig. 4c) and LUM (Extended Data Fig. 4a), suggesting that these two clusters could represent SMCs undergoing phenotypic modulation to become fibromyocytes. |
Title | Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. |
Authors | Robert C Wirka et al. |
Date | 2019.8 |
Data available | GSE131778 |