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ID 2349
Class Mammalia
Species Homo sapiens
Tissue Heart
Sample Tissue
Disease type coronary artery disease
Cell type Modulated smc
Cell type (subtype) Modulated smc
Cell marker FN1, LUM, CNN1
Frequency
PubMed ID 31359001
Journal Nat Med
SCI IF 36.13
Evidence The decrease in expression of CNN1 and other markers of SMC differentiation in these cell groups was accompanied by a corresponding increase in markers of SMC modulation, including FN1 (Fig. 4c) and LUM (Extended Data Fig. 4a), suggesting that these two clusters could represent SMCs undergoing phenotypic modulation to become fibromyocytes.
Title Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.
Authors Robert C Wirka et al.
Date 2019.8
Data available GSE131778