| Cell marker |
PTCRA, RAG1, RAG2, CD3E, CD3G, CD8B, CD1B, TCF7, BCL11B |
| Evidence |
Compared with embryonic ETP and fetal ETP1, T-lineage-specific genes were highly expressed in fetal ETP2, such as PTCRA, RAG1, RAG2, CD3E and CD3G (Takeuchi et al., 2001; Georgescu et al., 2008; Dik et al., 2005), as well as cell surface markergenes, like CD8B and CD1B (Figures 2D and S3B). More importantly, fetal ETP2 exhibited downregulation of stem- and progenitor-cell-related genes, such as CD34 and MEIS1 (Figures 2Dand 2E). The genes coding key TFs mediating T lymphocytespecialization, including TCF7 and BCL11B driven by NOTCHsignaling pathway (Weber et al., 2011; Li et al., 2010), werealso enriched in fetal ETP2 cluster (Figure 2E). |
