| Evidence |
First, we used the droplet-based scRNA-seq (cohort 1) to identify and annotate 18 distinct cell clusters spanning epithelial cells (five clusters marked by EPCAM, as well as cytokeratin- and kallikrein-encoding genes), macrophages (four clusters marked by CD14, AIF1, CSF1R and CD163), cancer-associated fibroblasts (CAFs) (four clusters marked by PDPN, DCN and THY1), dendritic cells (two clusters marked by CD1C, CD1E, CCR7 and CD83), B cells (CD19 and CD79A/B), T cells (CD2 and CD3D/E/G) and erythrocytes (GATA1 and hemoglobin-encoding genes) (Fig. 1b_d, Extended Data Fig. 8a, |
