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ID 3802
Class Mammalia
Species Homo sapiens
Tissue Ovary
Sample NA
Disease type high-grade serous ovarian cancer
Cell type Dendritic cells
Cell type (subtype) Dendritic cells
Cell marker CD1C, CCR7, CD83, CD1E
Frequency
PubMed ID 32572264
Journal Nat Med
SCI IF 36.13
Evidence First, we used the droplet-based scRNA-seq (cohort 1) to identify and annotate 18 distinct cell clusters spanning epithelial cells (five clusters marked by EPCAM, as well as cytokeratin- and kallikrein-encoding genes), macrophages (four clusters marked by CD14, AIF1, CSF1R and CD163), cancer-associated fibroblasts (CAFs) (four clusters marked by PDPN, DCN and THY1), dendritic cells (two clusters marked by CD1C, CD1E, CCR7 and CD83), B cells (CD19 and CD79A/B), T cells (CD2 and CD3D/E/G) and erythrocytes (GATA1 and hemoglobin-encoding genes) (Fig. 1b_d, Extended Data Fig. 5a,
Title A single-cell landscape of high-grade serous ovarian cancer
Authors Benjamin Izar et al.
Date 2020.8
Data available GSE146026