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ID 3495
Class Mammalia
Species Homo sapiens
Tissue Lymph node
Sample Tissue
Disease type Normal
Cell type Endothelial cells
Cell type (subtype) Lymphatic endothelial cells (LECs)
Cell marker C2, ACKR1, CCL21, IL33, TSPAN7, STAB2, LYVE-1, CSF1, F8, high Claudin-5, CD274, CLEC4G, CSF2RB, IL2RG, LTBP2, MARCO, TNC, CLEC4M, CD209, low PDPN
Frequency
PubMed ID 32426372
Journal Front Cardiovasc Med
SCI IF 3.917
Evidence Figure S8. Gray value intensity across the ROI for LYVE-1 (Marco-LECmarker) and MAdCAM-1 (fLEC marker) displaying decreasing or increasing expression along a path from the peri-follicular medullary sinuses to the SCS floor, respectively. In addition, CD209 and CLEC4M, which lack orthologs in Mouse (27), are specific for Human Marco-LECs. Figure 8. Staining of CD36 in Human head and neck LNs identified capillary-like, CD36high LYVE-1+ lymphatic cords, negative for MARCO and the Marco-LEC [LEC VI (27)] marker CLEC4M. ACKR1, also known as DARC (Duffy Antigen Receptor for Chemokines), marks Human fLECs and Marco-LECs, but Ackr1 has very low expression in Mouse LN LECs, without clear subset selectivity.
Title A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature
Authors Menglan Xiang et al.
Date 2020.4
Data available GSE143877, GSE145121