| Evidence |
We then combined single-cell RNA-seq data of B cells in NSCLC and in the blood (Fig. 2a). The B cells could be divided into two major groups (BC1 and BC2); the PBMCs contain 91.8% BC1 cells and 8.2% BC2 cells, while the NSCLC samples contain 61.8% BC1 cells and 39.2% BC2 cells (Fig. 2b). The BC1 cells express markers of na_ve B cells, such as MS4A1 (CD20), CD19, CD22, TCL1A, and CD83, and the BC2 cells express markers of the plasma B cells, such as CD38, TNFRSF17 (BCMA), and IGHG1/IGHG4 (Fig. 2c, d). |
