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ID 2991
Class Mammalia
Species Homo sapiens
Tissue Liver
Sample NA
Disease type Fibrolamellar carcinoma
Cell type Stromal cells
Cell type (subtype) Tumor associated stromal cells
Cell marker ACTA2
Frequency
PubMed ID 31669305
Journal Am J Pathol
SCI IF 3.491
Evidence the two smaller Human clusters (2 and 3) were not enriched with classical FLC markers. Rather, they were characterized by expression of extracellular matrix components, including collagen 1- alpha-1 and multiple other forms of collagen (Supplementary Fig S2). Mesenchymal and stromal marker genes, such as alphaSMA (ACTA2), were also most abundant in clusters 2 and 3 (Fig 2C). Therefore, these clusters are Human tumor-associated stromal cells that have been maintained in explant passaging.
Title Single cell RNA sequencing identifies YAP1-dependent hepatic mesothelial progenitors in fibrolamellar carcinoma
Authors Mark L et al.
Date 2020.1
Data available NA