Search | Result

ID 2435
Class Mammalia
Species Homo sapiens
Tissue Heart
Sample Tissue
Disease type Calcific aortic valve disease
Cell type Interstitial cells
Cell type (subtype) Valve interstitial cells (vics)
Cell marker COL1A1, COL3A1, FOS, HSPA6, SPARC
Frequency
PubMed ID 33086873
Journal Thromb Vasc Biol
SCI IF 6.604
Evidence In addition to the 3 subpopulations of VICs, which included cluster 7 (FOS, COL1A1, COL3A1), cluster 10 (HSPA6, COL1A1, COL3A1), and cluster 13 (COL1A1, COL3A1, SPARC), we identified the following monocytic cell cluster:cluster 5 (CXCL1, CXCL3, PTX3); VECs:cluster 11 (SELE, IL1RL1, SER, PINE1) and cluster 12 (SELE, SER_x005f_x005f_x005f_x0002_PINE1, PI3); macrophages; cluster 9 (CCL3L1, CXCL5, CCL4); lymphocytes; IIC in the Data Supplement). As the top 5 potential marker genes failed to demonstrate significant specificity, the most expressed gene in each cluster was selected as a potential marker for identifying these notable cell populations (LUM for cluster 1, SOX4 for cluster 2, CCL20 for cluster 3, MT1A for Cluster 4, RPL17 for cluster 6, CMSS1 for cluster 8
Title Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease
Authors Kang Xu et al.
Date 2020.12
Data available NA