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ID 2364
Class Mammalia
Species Homo sapiens
Tissue Heart
Sample Cell line
Disease type NA
Cell type Cardiac cells
Cell type (subtype) Cardiac progenitors
Cell marker ISL1, CKIT, MESP1, MESP2
Frequency
PubMed ID 32619518
Journal Cell Stem Cell
SCI IF 25.269
Evidence Importantly, GSK-3beta inhibition did not result in increased expression of the cardiac progenitor markers such as CKIT, ISL1 or MESP1/2 (Figure S2F), suggesting that expansion of functional hiPSC-CMs with CHIR does not lead to expansion of a rare population of residual cardiac mesoderm or second-heart-field progenitor cells.
Title Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
Authors Jan W Buikema et al.
Date 2020.7
Data available GSE148586