| Evidence |
Within the fibroblast cluster, the expression of COL1A2 appeared similar, but the metastatic tumor fibroblasts expressed considerably more RGS5.Consistent with the greater number of fibroblasts in the primary tumor, the primary tumor showed a possible paracrine inductive interaction between the most differentiated synaptic tumor cells (expressing PDGFA) and fibroblasts (expressing PDGFRA), but the metastasis did not.In contrast, the metastatic pericytes expressed considerably higher levels of PDGRB, a known pericyte marker.The synaptic subtype differentially expressed nine genes encoding synaptic proteins or proteins essential for synaptic function, four of which are shown in Figure 1B (DNM1, CADPS, SYT7, and SLC18A2) |
