| Evidence |
The large CL1 linked weakly to the central endothelial network, expresses predominantly arterial markers (GJA5 and HEY2), and is referred to as arterial endothelium. However, some markers considered to be arterial, including SOX7, SOX17, NOTCH1, and NRP1, are expressed across the central endothelial network and CL1, suggesting ambiguity in distinction between arterial and venous endothelium. Our observation is in line with evidence that hESC-derived hematogenic endothelium is negative for arterial (KDR) and venous (NT5E) markers and emerges separately from the arterial endothelium. |
