Search | Result

ID 2026
Class Mammalia
Species Homo sapiens
Tissue Cornea
Sample Tissue
Disease type Normal
Cell type Amplifying cell
Cell type (subtype) Transiently amplifying cells (TACs)
Cell marker MKI67, BIRC5, RRM2, BIRC5, RRM2, TOP2A, MKI67, PLK1
Frequency
PubMed ID 33388438
Journal Ocul Surf
SCI IF 12.336
Evidence The clustering result was annotated by the known markers including KRT12, KRT3 and GJA1 for differentiated cell; KRT14, KRT15 and KRT19 for progenitor; MKI67, BIRC5 and RRM2 for amplifying cell; TCF4, POSTN and A2M for LSC; TYR, TYRP1 and MLANA for melanocyte; and KRT4, KRT7 and KRT13 for conjunctival cells (Fig. 2F).C8 was the only cluster highly expressing major proliferation markers, including BIRC5, RRM2, TOP2A, MKI67 and PLK1 (Fig. 3A, C). This is consistent with the cell cycle analysis (Fig. 2D), which shows 98% of C8 cells in S and G2/M phases. Therefore, C8 is likely to be transiently amplifying cells (TACs) that are about to exit cell cycle and differentiate into corneal epithelial cells.
Title Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of Human cornea
Authors De-Quan Li et al.
Date 2021.1
Data available GSE153515