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ID 1340
Class Mammalia
Species Homo sapiens
Tissue Brain
Sample Organoids
Disease type NOD/scid/IL2rg (NSG)
Cell type Mural cells
Cell type (subtype) Mural cells
Cell marker PDGFRB, FOXF2, RGS5, CD248, CD19, CSPG4
Frequency
PubMed ID 32961131
Journal Cell
SCI IF 38.653
Evidence These populations were identified based on the expression canonical marker genes; mural cells specifically expressed expected marker genes, such as PDGFRB, FOXF2, RGS5, and CD248, while Endothelial cellss expressed a distinct set of markers, including CDH5 and PECAM1 (CD31; Figure 1D). In contrast, mural meta-cells at GW25 displayed high and specific expression of mural cell marker genes, such as CD248, RGS5, and FOXF2, in addition to specific expression of CD19 (Figure S2F). We identified a subset of non-neuronal clusters enriched for mural marker genes (CD248, CSPG4) and confirmed that this population expressed both CD19 and CD81 (Figures S3B and S3C)
Title Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Authors Kevin R Parker et al.
Date 2020.1
Data available GSE153647