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ID 1496
Class Mammalia
Species Homo sapiens
Tissue Brain
Sample Tissue
Disease type Alzheimer disease
Cell type Microglia cells
Cell type (subtype) Microglia cells
Cell marker CX3CR1, P2RY12, TMEM119, P2RY13, CCL2, CXCL10, CCL8, CXCL11
Frequency
PubMed ID 31375314
Journal Neuron
SCI IF 14.415
Evidence Interestingly, canonical microglia markers (P2RY12, P2RY13, CX3CR1, and TMEM119) showed a relatively even distribution across most clusters but decreased expression within the DAM clusters a cluster defined by high levels of inflammatory chemokines (purple; CCL2, CXCL10, CCL8, and CXCL11)
Title Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo
Authors Jonathan Hasselmann et al.
Date 2019.9
Data available GSE133437