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ID 2761
Class Mammalia
Species Homo sapiens
Tissue Kidney
Sample Tissue
Disease type lupus nephritis
Cell type CD8 T cells
Cell type (subtype) Resident memory cells
Cell marker GZMK, ZNF683, XCL1, ITGA1, KLF2, ITGAE, HOBIT
Frequency
PubMed ID 31209404
Journal Nat Immunol
SCI IF 20.479
Evidence A second population of CD8+ T cells, demonstrating high levels of the granzyme GZMK (ref. 24) rather than GZMB and GNLY, populated cluster CT4. The cells in cluster CT5a had features of resident memory cells, including expression of ZNF683 (HOBIT), ITGAE, ITGA1 and XCL1, and lack of KLF2
Title The immune cell landscape in kidneys of patients with lupus nephritis
Authors Arnon Arazi et al.
Date 2019.7
Data available phs001457.v1.p1