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ID 1308
Class Mammalia
Species Homo sapiens
Tissue Blood
Sample NA
Disease type Stage IV metastatic melanoma
Cell type CD8 T cells
Cell type (subtype) CD8+CD39_CD69_ TIL
Cell marker LEF1, IL7R, SELL, TCF7, KLF2, CD27, S1PR1
Frequency
PubMed ID 33303615
Journal Science
SCI IF 41.845
Evidence Cluster 1, which was four times more abundant in CR infusion products relative to NR infusion products (corrected P = 0.0264; Fig. 1D), corresponded to CD8+ T cells with high expression of CD44, CD27, and CD28 and low expression of TIM3, characterized in prior studies as memory-like (18) and stem-like (22) T cells (Fig. 1C)
Title Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against Human cancer
Authors Krishna et al.
Date 2020.12
Data available NA