Search | Result
| ID | 1307 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Blood |
| Sample | Blood |
| Disease type | Progressive lung fibrosis |
| Cell type | Epithelial cells |
| Cell type (subtype) | Epithelial cells |
| Cell marker | APOE, APOC1, TREM2, CYP27A1, LIPA, MMP9 |
| Frequency | |
| PubMed ID | 33294861 |
| Journal | Cell Rep Med |
| SCI IF | 37.218 |
| Evidence | displayed relative upregulation of genes associated with lipid metabolism and lipoprotein recognition (APOC1, APOE, and TREM2) as well as genes associated with degradation of lipids and extracellular matrix (CYP27A1, LIPA, and MMP9). Secretion of matrix metalloproteinases (e.g., MMP9) by macrophages is a key component of their extracellular matrix turnover function |
| Title | Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis |
| Authors | Xia Gao et al. |
| Date | 2020.11 |
| Data available | GSE155687 |
