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ID 4338
Class Mammalia
Species Homo sapiens
Tissue Skin
Sample Tissue
Disease type Normal
Cell type Fibroblasts
Cell type (subtype) A1 fibroblasts
Cell marker MMP2, SFRP2, ELN, QPCT, PI16, IGFBP6, WISP2, SLPI
Frequency
PubMed ID 33385399
Journal J Invest Dermatol
SCI IF 7.143
Evidence Axis A (Figure 1, red; SFRP2 is shown for illustration) represents 49.5 6.7% of the fibroblasts and is defined by ELN; MMP2; QPCT; and SFRP2 expression (Supplementary Figure S1). Axis B (Figure 1, green; APOE is shown for illustration) represents 30.5 3.0% of the fibroblasts and is defined by APOE, C7, CYGB, and IGFBP7 expression (Supplementary Figure S2). Axis C (Figure 1, blue; SFRP1 is shown for illustration) represents 16.2 9.3% of the fibroblasts and is defined by DKK3, TNMD, TNN, and SFRP1 expression (Supplementary Figure S3).Cluster A1 (Figure 2, pink; SLPI is shown for illustration) represents 42.7 5.7% of the type A fibroblasts and is defined by IGFBP6, PI16, SLPI, and WISP2 expression (Supplementary Figure S4).
Title Human Dermal Fibroblast Subpopulations Are Conserved across Single-Cell RNA Sequencing Studies
Authors Alex M Ascension et al.
Date 2020.12
Data available GSE130973