Search | Result
| ID | 935 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Blood |
| Sample | Blood |
| Disease type | Mild Cognitive Impairment (MCI) or Alzheimer's disease(AD) |
| Cell type | Natural killer T (NKT) cells |
| Cell type (subtype) | Natural killer T (NKT) cells |
| Cell marker | NKG7, GZMA, GZMH, GZMK |
| Frequency | |
| PubMed ID | 31915375 |
| Journal | Nature |
| SCI IF | 49.962 |
| Evidence | Differential expression analysis of clones that were highly expanded in MCI and AD (that is, more than five T_ells with the same TCRalphabeta sequence) revealed increased expression of cytotoxic effector genes, including natural killer cell granule protein 7 (NKG7) and granzymes A, H and K (GZMA, GZMH and GZMK) |
| Title | Clonally expanded CD8 T_ells patrol the cerebrospinal fluid in Alzheimer's disease |
| Authors | David Gate et al. |
| Date | 2019.2 |
| Data available | GSE134578 |
