Search | Result
| ID | 3105 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Lung |
| Sample | Tissue |
| Disease type | Lymphangioleiomyomatosis |
| Cell type | Alveolar cells |
| Cell type (subtype) | Fibrotically activated macs |
| Cell marker | PDGFRa, DCN, SFRP4, COL3A1, COL1A1, ACTA2 |
| Frequency | |
| PubMed ID | 33159078 |
| Journal | Nat Commun |
| SCI IF | 12.121 |
| Evidence | In control lung, the alveolar epithelial cell (AEC)niche was divided into two canonical clusters: alveolar type 2(AT2), marked by the high differential expression of SFTPC, SFTPD, and SFTPA genes, and alveolar type-1 (AT1) cells, characterized by HOPX, AGER, and AQP4 gene expression |
| Title | mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. |
| Authors | Obraztsova K et al. |
| Date | 2020.11 |
| Data available | GSE139819 |
