Search | Result
| ID | 8690 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | Small intestine |
| Sample | NA |
| Disease type | Normal |
| Cell type | Tuft cells |
| Cell type (subtype) | Tuft-2 cells |
| Cell marker | Il4ra, Il13ra1, Ptprc, CD45 |
| Frequency | |
| PubMed ID | 29144463 |
| Journal | Nature |
| SCI IF | 49.962 |
| Evidence | Tuft-2 cells expressed significantly higher levels of the Th2 promoting cytokine, thymic stromal lymphopoietin (TSLP)34 (FDR<0.1, Mann-Whitney U-test, Fig. 4c), which we confirmed with smFISH and qPCR (Extended Data Fig. 7f, g). Tuft cells also specifically expressed receptors for the Th2-related cytokines Il4ra and Il13ra1 and for IL-25 (Il17rb) Surprisingly, Ptprc, encoding the pan-immune marker CD45, was expressed strongly and exclusively by Tuft-2 cells |
| Title | A single-cell survey of the small intestinal epithelium |
| Authors | Haber Adam L et al. |
| Date | 2017.11 |
| Data available | GSE92332 |
