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ID 8599
Class Mammalia
Species Mouse
Tissue Skin
Sample Tissue
Disease type Wounded
Cell type T cells
Cell type (subtype) T-lymphocyte cells
Cell marker Cd3d, Nkg7, Thy1, Icos, Maf, Cd81
Frequency
PubMed ID 30737373
Journal Nat Commun
SCI IF 12.121
Evidence myeloid markers, including C1qb, Cd14, Cd68, Lyz2, Mafb, and Pf4 (Supplementary Figure 3b; Supplementary Data 1). Cluster C7 cells were classified as T lymphocytes (~4%) and they expressed Cd3d, Cd81, Icos, Maf, Nkg7, and Thy1 (Supplementary Figure 4). Cluster C8 cells were identified as B lymphocytes (~3%) and C12 as dendritic cells (~1%). Two other distinct cell clusters were C5 (~9%) and C13 (~1%). Cluster C5 cells were enriched for endothelial markers Cav1, Cd34, Cd93, Ly6e, Ly6c1, and Pecam1, while cluster C13 cells—for lymphatic endothelial markers Ccl21a, Lyve1, Pdpn, and Prox1. Cluster C10 cells (~1%) were classified as Schwann cells based on expression of Cadm4, Dbi, Gpm6b, Itih5, and Plp1.
Title Single-cell analysis reveals fibroblast heterogeneity and myeloid derived adipocyte progenitors in murine skin wounds
Authors Christian F Guerrero-Juarez et al.
Date 2019.2
Data available GSE113854 & GSE113605