| Evidence |
our results identified monocyte (Cd14, Fcgr3), macrophage (Adgre1, Csf1r), dendritic cell (Flt3), T cell (Cd3g, Cd4, Cd8b1) and natural killer cell (Ncr1), B cell (Cd19, Cd79a, Jchain) and plasma cell (Jchain, Sdc1), Endothelial cells (Pecam1, Cdh5), and mesenchymal stromal/stem cell (MSC, expressing Lum, Dcn, Cd34, Pdgfra) (Online Figure III).Further analysis of antigen presenting gene features identified three B cell clusters (cluster 1, 2, 3) with possible high MHCII antigen presenting capacities, further annotated as antigen-presenting B cells (Figure 4E). These clusters also expressed Ccr7, Cxcr4 and Cxcr5 (Online Figure VA), chemokines that are required for B cell homing31. |
