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ID 8493
Class Mammalia
Species Mouse
Tissue Skeletal muscle
Sample Tissue
Disease type Normal
Cell type Myonuclei
Cell type (subtype) MTJ
Cell marker Titin, Col22a1, Erbb4
Frequency
PubMed ID 33037211
Journal Nat Commun
SCI IF 12.121
Evidence At the NMJ, specific myonuclei express AchR and AchE and at the MTJ-specific myonuclei express Col22a1;To look at the heterogeneity of the myonuclei, we have then reclustered the myonuclei expressing Titin (Ttn) gene to remove all the non-fiber nuclei (Fig. 1c).Several populations of myonuclei where identified, among which MTJ myonuclei (expressing Col22a1), NMJ myonuclei (expressing Ache), a yet unknown myonuclei subpopulation (expressing Myh9, Flnc, Runx1), and body myonuclei accounting for 94% of all myonuclei (Figs. 1c and 2a)
Title Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
Authors Matthieu Dos Santos et al.
Date 2020.1
Data available GSE150065