Search | Result
| ID | 3450 |
|---|---|
| Class | Mammalia |
| Species | Homo sapiens |
| Tissue | Lung |
| Sample | NA |
| Disease type | Nonsmall cell lung cancer |
| Cell type | CD8 T cells |
| Cell type (subtype) | CD8 T cells |
| Cell marker | CD8A, CD3E, PDCD1, IL18BP |
| Frequency | |
| PubMed ID | 32581358 |
| Journal | Nature |
| SCI IF | 49.962 |
| Evidence | Correlation of IL18BP expression with T cell markers CD3E (b), CD8A (c), and PDCD1 (d) from the TCGA database. Expression of IL18BP strongly correlated with CD3E, CD8A, and PDCD1 (R = 0.59 to 0.88), indicating an association with the presence of activated CD8+ T cells (Extended Data Fig. 2b_d). |
| Title | IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy |
| Authors | Ting Zhou et al. |
| Date | 2020.7 |
| Data available | GSE146609 |
