| Evidence |
the differentiation trajectory of Mouse enteric NC for the neuronal lineage began with the Mouse bipotent progenitors (BPs) (mBP; c1), passed through 2 intermediates inferred using PCA (mNPearly; c2 and c3), and terminated at a more mature neuron state (mNPlate; c4 _ubb3high, _lavl4_igh). Another distinct population of progenitors (c8) was found, and these cells coexpressed a unique NC invasion signature (Acta2high, _ctg2_igh, _agn_igh, _and1_igh, _nail2_igh, _ox10low) that were previously identified from the migratory font of NC stream in an avian model, 25_esembling the highly migratory population of NC cells (Supplementary Figure2). Three populations of glial progenitors (GPs) (mGP; c5, c6, and c7) expressing the early glial markers (Fabp7, _lp1, and_ox10) were also identified. |
