Search | Result
| ID | 7909 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | NA |
| Sample | Tissue |
| Disease type | Tumors |
| Cell type | Fibroblasts |
| Cell type (subtype) | Cancer associated fibroblasts (CAFS) |
| Cell marker | Pdpn, Fap |
| Frequency | |
| PubMed ID | 33298926 |
| Journal | Nat commun |
| SCI IF | 12.121 |
| Evidence | Mesenchymal cells were identified by lack of endothelial (Pecam1, encoding for CD31) and hematopoietic (Ptprc, encoding for CD45) cell markers, and by expression of mesenchymal genes uch as Thy1 and Fap. Expression of Pdpn was used to further distinguish between CAFs (Fap+Pdpn+) and cancer-associated pericytes (CAPs, Fap+Pdpn-), as previously described |
| Title | TGFbeta-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts |
| Authors | Angelo L Grauel et al. |
| Date | 2020.12 |
| Data available | GSE160687 |
