Evidence |
These cells were identifed by high expression of the stem cell markers CTLA2A, HLF, and CD34 and the absence of lineage-specifc gene expression (Figure 6B). Gene expression patterns of all major lineages were represented in the single-cell analysis, albeit at varying levels. These include DC progenitors (CD74, H2-AA, and H2-EB1 high), erythrocyte progenitors (HBB-BT high), lymphoid progenitors (DNTT high), monocyte progenitors (IRF8 and LY86 high), egakaryocyte/basophil progenitors (VWF and GATA2 high), neutrophil progenitors (MPO and CTSG high), and pre-B and T cell progenitors (EBF1/CD19 high and TRBC1 high, respectively) |