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ID 7882
Class Mammalia
Species Mouse
Tissue NA
Sample NA
Disease type NA
Cell type Monocytes
Cell type (subtype) Monocyte progenitors
Cell marker LY86, IRF8
Frequency
PubMed ID 32641586
Journal JCI Insight
SCI IF 6.05
Evidence These cells were identifed by high expression of the stem cell markers CTLA2A, HLF, and CD34 and the absence of lineage-specifc gene expression (Figure 6B). Gene expression patterns of all major lineages were represented in the single-cell analysis, albeit at varying levels. These include DC progenitors (CD74, H2-AA, and H2-EB1 high), erythrocyte progenitors (HBB-BT high), lymphoid progenitors (DNTT high), monocyte progenitors (IRF8 and LY86 high), egakaryocyte/basophil progenitors (VWF and GATA2 high), neutrophil progenitors (MPO and CTSG high), and pre-B and T cell progenitors (EBF1/CD19 high and TRBC1 high, respectively)
Title Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes
Authors Cristiano P Vieira et al.
Date 2020.7
Data available NA