ID |
7862 |
Class |
Mammalia |
Species |
Mouse |
Tissue |
NA |
Sample |
Tissue |
Disease type |
melanoma tumors |
Cell type |
Natural killer (NK) cells |
Cell type (subtype) |
ILC1s |
Cell marker |
Pd1, Pdcd1, Trail, Tfnsf10 |
Frequency |
|
PubMed ID |
31398344
|
Journal |
Cell |
SCI IF |
38.637 |
Evidence |
nockout of tumor IFNGR results in a large shift in the NK populations toward the mature CD11bhigh cluster and an additional shift toward the ILC1 cluster (Figure 4F, density plots). These ILC1s exhibit relatively high levels of Pd1 (Pdcd1) and Trail (Tfnsf10) |
Title |
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade |
Authors |
Joseph L Benci et al. |
Date |
2019.8 |
Data available |
GSE72056, GSE131928 |