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ID 7862
Class Mammalia
Species Mouse
Tissue NA
Sample Tissue
Disease type melanoma tumors
Cell type Natural killer (NK) cells
Cell type (subtype) ILC1s
Cell marker Pd1, Pdcd1, Trail, Tfnsf10
Frequency
PubMed ID 31398344
Journal Cell
SCI IF 38.637
Evidence nockout of tumor IFNGR results in a large shift in the NK populations toward the mature CD11bhigh cluster and an additional shift toward the ILC1 cluster (Figure 4F, density plots). These ILC1s exhibit relatively high levels of Pd1 (Pdcd1) and Trail (Tfnsf10)
Title Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
Authors Joseph L Benci et al.
Date 2019.8
Data available GSE72056, GSE131928