Search | Result
| ID | 7861 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | NA |
| Sample | Tissue |
| Disease type | melanoma tumors |
| Cell type | CD8 T cells |
| Cell type (subtype) | Expanded CD8 T cells |
| Cell marker | Pdcd1, Eomes, Cd38 |
| Frequency | |
| PubMed ID | 31398344 |
| Journal | Cell |
| SCI IF | 38.637 |
| Evidence | Gene set enrichment analysis (GSEA) using transcriptional signatures of these exhausted subsets (defined using the LCMV infection model) revealed that the expanded CD8 T cells resulting from IFNGR knockout show a marked increase in terminal exhaustion genes (e.g., Pdcd1, Eomes, Cd38) and a decrease in progenitor exhaustion genes (e.g., Tcf7) |
| Title | Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade |
| Authors | Joseph L Benci et al. |
| Date | 2019.8 |
| Data available | GSE72056, GSE131927 |
