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ID 7826
Class Mammalia
Species Mouse
Tissue NA
Sample NA
Disease type NA
Cell type Dn2 cells
Cell type (subtype) Dn2 cells
Cell marker Cd117, Cd44, Hoxa9, Lmo2, Mef2c, Gfi1b, Lyl1, Spi1, Bcl11a, Mycn, Hhex
Frequency
PubMed ID 30765463
Journal J Exp Med
SCI IF 11.052
Evidence As genes specific for the DN2 stage, Cd117, Cd44, Hoxa9, Lmo2, Mef2c, Gfi1b, Lyl1, Spi1, Bcl11a, Mycn, and Hhex were used. Il2ra, Il7r, Erg, Notch1, Hes1, and Runx1 were used as genes expressed in both DN2 and DN3 cells. DN3 cells in particular were defined by high expression of CD3gamma, CD3delta, CD3ε, Rag1, Rag2, Ptcra, Tcf12, Ets, Ahr, Notch3, and SpiB. From the DN3 stage onward, Tcf12, Ets1, Bcl11b, Ets2, Lef1, Thy1, and Themis are highly expressed, whereas Cd4, Cd8, Rorc, and Id3 are increased once the cells have reached DN4 stage.
Title The transcription factor Duxbl mediates elimination of pre-T cells that fail beta-selection
Authors Fabian Klein et al.
Date 2019.3
Data available GSE118059