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ID 7783
Class Mammalia
Species Mouse
Tissue Muscle
Sample Tissue
Disease type Duchenne muscular dystrophy
Cell type Myonuclei
Cell type (subtype) IIx
Cell marker Ckm, Myh1
Frequency
PubMed ID 33148801
Journal Proc Natl Acad Sci U S A
SCI IF 9.412
Evidence As seen by UMAP, several clusters of nuclei were detected that express Ckm, a marker of mature myonuclei (Fig. 2 B and C and SI Appendix, Fig. S4B). These Ckm+ nuclei express different isoforms of myosin heavy chain (Myh), the classical marker for myofiber classification (19). We identified two large clusters of myonuclei with high levels of expression of Myh isoforms Cluster IIx expressed high levels of Myh1, which encodes myosin heavy chain protein IIx (MyHC-IIx), and Cluster IIb had high levels of expression of Myh4, encoding MyHC-IIb.
Title Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
Authors Francesco Chemello et al.
Date 2020.11
Data available GSE156498