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ID 7782
Class Mammalia
Species Mouse
Tissue Muscle
Sample Tissue
Disease type Duchenne muscular dystrophy
Cell type Mph
Cell type (subtype) Mph
Cell marker Adgre1
Frequency
PubMed ID 33148801
Journal Proc Natl Acad Sci U S A
SCI IF 9.412
Evidence As expected, snRNAseq of skeletal muscle also detected clusters of nuclei from othermononucleated cell types, such as Cluster SMC, containing nuclei from smooth muscle cells, as identified by expression ofMyh11; Cluster EC, containing nuclei from Endothelial cellss, ascharacterized by expression of the adhesive stress-responseprotein Pecam-1 (25); Cluster FAP, containing nuclei fromFAP cells, as characterized by expression of Pdgfra (26); ClusterTC, containing nuclei from tenocytes, as characterized by expression of the tenogenesis-promoting homeoprotein Mkx (27);and Cluster MPH, containing nuclei from macrophages, ascharacterized by expression of Adgre1
Title Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
Authors Francesco Chemello et al.
Date 2020.11
Data available GSE156498