Search | Result
| ID | 7636 |
|---|---|
| Class | Mammalia |
| Species | Mouse |
| Tissue | Lymph node |
| Sample | Tissue |
| Disease type | Normal |
| Cell type | Endothelial cells |
| Cell type (subtype) | Lymphatic endothelial cells (LECs) |
| Cell marker | Kdr, Ccl21a, Lyve1, Stab2, Flt4, Reln, Angpt2, Mgll, Mrc1, Tgfbi, Itih5, Npr1, Npr2, Ptx3 |
| Frequency | |
| PubMed ID | 32426372 |
| Journal | Front Cardiovasc Med |
| SCI IF | 3.917 |
| Evidence | Figure 8. Ox1 shows reduced expression of fLEC marker genes Cd74 and Bmp2, and Ox2 of Ptx3-LEC marker genes including Stab2 and Tgfb. The Ptx3-LEC marker Reelin (Reln) is an extracellular matrix glycoprotein. The Ptx3-LEC marker Angiopoietin 2 (Angpt2) has also been linked to LEC proliferation (75, 76), it can induce lymphatic hyperplasia when overexpressed (76) and is highly expressed by newly formed lymphatic vessels in inflammation-induced lymphangiogenesis. |
| Title | A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature |
| Authors | Menglan Xiang et al. |
| Date | 2020.4 |
| Data available | GSE143877, GSE145121 |
