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ID 7583
Class Mammalia
Species Mouse
Tissue Lung
Sample Tissue
Disease type Lung tumor
Cell type Epithelial cells
Cell type (subtype) Epithelial cells
Cell marker Epcam
Frequency
PubMed ID 33357452
Journal Cancer Cell
SCI IF 26.602
Evidence Unsupervised clustering analysis revealed populations that we identi_ed based on lineage and phenotypic marker expression as tumor/epithelial cells (Epcam), Endothelial cellss (Pecam1), B cells (Cd19), NK cells (Klrb1c), T cells (Cd3d), the CAR-T cell infusion product (CAR transgene), neutrophils (Cxcr2, S100a9), red blood cells (Hba-a1), plasmacytoid dendritic cells (DCs) (Siglech), plasma B cells (Tnfrsf17), and mononuclear phagocytes (MNPs) that shared variable expression of macrophage, DC, and monocyte markers (e.g., Cd68, Itgax, Itgam, Adgre1)
Title Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Authors Shivani Srivastava et al.
Date 2020.12
Data available GSE158109