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ID 7545
Class Mammalia
Species Mouse
Tissue Lung
Sample Tissue
Disease type Lung tumor
Cell type Red cells
Cell type (subtype) Red blood cells
Cell marker Hba-a1
Frequency
PubMed ID 33357452
Journal Cancer Cell
SCI IF 26.602
Evidence Unsupervised clustering analysis revealed populations that we identi_ed based on lineage and phenotypic marker expression as tumor/epithelial cells (Epcam), Endothelial cellss (Pecam1), B cells (Cd19), NK cells (Klrb1c), T cells (Cd3d), the CAR-T cell infusion product (CAR transgene), neutrophils (Cxcr2, S100a9), red blood cells (Hba-a1), plasmacytoid dendritic cells (DCs) (Siglech), plasma B cells (Tnfrsf17), and mononuclear phagocytes (MNPs) that shared variable expression of macrophage, DC, and monocyte markers (e.g., Cd68, Itgax, Itgam, Adgre1)
Title Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Authors Shivani Srivastava et al.
Date 2020.12
Data available GSE158109