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ID 7205
Class Mammalia
Species Mouse
Tissue Liver
Sample Tissue
Disease type liver regeneration
Cell type Progenitor cells
Cell type (subtype) Bipotent liver progenitors
Cell marker Gata6, Yap
Frequency
PubMed ID 33208554
Journal JCI Insight
SCI IF 6.205
Evidence The number of cells expressing genes that promote adult hepatocyte dedifferentiation intobipotent liver progenitors (Yap, Gata6) (7, 8) and mark hepatocyte precursors (AFP) (9) or immature cholangiocytes (e.g., Sox9, Hnf1b) (10, 11) also increased (Supplemental Figure 3F).
Title Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration
Authors Tianyi Chen et al.
Date 2020.11
Data available GSE158866 [scRNA-Seq], and GSE158873 [scATAC-Seq]